Publications

2026

Tero Kämäräinen, SaraLi Deuso, Stephan Müssig, Leoni Luthardt, Yuta Hatanaka, Yuichi Tozuka, Kazunori Kadota , Karl Mandel .

Assembly of filament-like supraparticles in confined vortex rings.

Journal of Colloid and Interface Science,Volume 703, Part 1, February 2026, 139039,https://doi.org/10.1016/j.jcis.2025.139039

2025

Mayumi Ikeda-Imafuku, Maki Sakai, Keitaro Umezawa, Hidehiko Nakagawa, Toru Maruyama, Masaki Otagiri, Takaaki Akaike, Tomohiro Sawa, Ming Xian, Yuri Miura, Tatsuhiro Ishida & Yu Ishima.

Unique response of polysulfide in serum albumin to oxidative stress.

Sci Rep 15, 42689 (2025). https://doi.org/10.1038/s41598-025-26702-w

Ryoma Tanaka, Miki Nagatani, Ryuta Togashi, Katsuhiko Minoura,Hiromasa Uchiyama, Shunsuke Tanaka, Yuichi Tozuka, Kazunori Kadota.

Physically stable cyclodextrin metal–organic frameworks formed via a drug-assisted amorphous to crystal phase transition.

CrystEngComm, 2025, 27,7121-7127, DOI: 10.1039/d5ce00755k

Yuzuki Nakayama, Tero Kämäräinen, Hiromasa Uchiyama, Yuichi Tozuka, and Kazunori Kadota.

Role of Amyloid Nanofibrils in Drug Incorporation and Release from Wrinkled Supraparticles.

ACS Applied. Nano Materials. 2025, 8, 13438−13450, https://doi.org/10.1021/acsanm.5c02143

Peiwen Mo, Yuta Hatanaka, Saki Ohta, Yuzuki Nakayama, Yasuteru Mawatari, Shinya Yamanaka,

Katsuhiko Minoura, Mitsunobu Doi, Hiromasa Uchiyama, Kazunori Kadota, and Yuichi Tozuka.

Development of Cocrystal and Coamorphous Salts of Moxifloxacin with Artificial Sweeteners to Suppress Bitterness.

Crystal Growth& Design. 2025, 25, 4283−4294,https://doi.org/10.1021/acs.cgd.5c00170

Yuki Takegawa, Misaki Sugimoto, Hiromasa Uchiyama, Kazunori Kadota, Yuichi Tozuka.
Construction of a modified Arrhenius equation for predicting drug nitrosation in solid dosage form.
International Journal of Pharmaceutics,Volume 685,2025,https://doi.org/10.1016/j.ijpharm.2025.126212.

Rentaro Sakamoto, Yuki Koba, Masahiko Nakamoto, Tatsuya Fukuta, Kazunori Kadota, Michiya Matsusaki

Emergence of a Cell-Guided Multivalent Ligand of Enzymes on Cancer Cells Triggered by Click Reaction between Hetero Nano-Assemblies

ACS Appl. Mater. Interfaces 2025, 17, 59726−59736

Yi Sun, Guixiang Lv, Zheng Hu, Mengyu Chen, Wuxuan Liu, Mayumi Ikeda-Imafuku, Tatsuya Fukuta, Kazunori Kadota, Xiangwei Li, Enze Li.

Thermosensitive hydrogel delivering a self-reinforced dual cascade nanoreactor for synergistic cuproptosis induction and immune microenvironment remodeling.

Chemical Engineering Journal,Volume 522,2025,https://doi.org/10.1016/j.cej.2025.167867.

Fukuta Tatsuya, Miyazaki Masato, Nakamura Haruhiko, Matsui K, Kodama S, Ikeda-Imafuku Mayumi, Higashi K, Kadota Kazunori.

Scalable Preparation of Extracellular Vesicles Encapsulating Anticancer Drugs by High-Pressure Homogenization for Targeted Cancer Therapy

ACS Biomater Sci Eng, 11, 5440-5453 (2025)

Tatsuhiko Nakamura, Haruka Manose, Yuta Hatanaka, Hiromasa Uchiyama, Yuichi Tozuka, and Kazunori Kadota.
Eco-Friendly Dry Melt Coating of Tannic Acid Particles With Glycerol Monostearate and Amino Methacrylate Copolymer for Effective Taste Masking.
ACS Food Science & Technology 2025 5 (5), 1918-1929,DOI: 10.1021/acsfoodscitech.5c00102

Syafhira Putri Aulia, Aida Nadia, Dicky Annas, Lenny Marlinda, Mohammad Jihad Madiabu, Sun Theo Constan Lotebulo Ndruru, Anita Marlina, Khoiriah Khoiriah, Vivi Sisca, Fildzah ‘Adany, Amalia Kurnia Amin, Muhammad Al Muttaqii, Muhammad Iqbal Syauqi, Tabah Ditalistya, Yuichi Tozuka, Kazunori Kadota, Tero Kämäräinen, Robertus Wahyu N. Nugroho.

Sustainable green synthesis of CoFe2O4/TiO2 magnetic nanocomposites using Parkia speciosa (stinky bean) peel extract as an electrocatalyst for hydrogen production.

Vacuum.Volume 239,2025,114378,ISSN 0042-207X,https://doi.org/10.1016/j.vacuum.2025.114378.

Tatsuya Fukuta, Kotone Yoshimura, Rikuto Ihara, Katsuhiko Minoura, Mayumi Ikeda-Imafuku, Kazunori Kadota. (*Corresponding author, #Equal contribution).

Intracerebral delivery of the ionic liquid form of edaravone via nose-to-brain delivery route for treating cerebral ischemia/reperfusion injury.

Journal of Controlled Release, 383, 113834 (2025).

Tatsuya Fukuta, Suyog Shaha, Andres da Silva-Candal, Zongmin Zhao, Samir Mitragotri.

Cell therapies against brain tumors: Clinical development and emerging prospects.

Bioengineering and Translational Medicine, e70018 (2025). https://doi.org/10.1002/btm2.70018

Hiroshi Ueda, Jun Yee Tse,Tetsuya Miyano,Yuzuki Nakayama,Peiwen Mo,Yuta Hatanaka,Hiromasa Uchiyama, Yuichi Tozuka and Kazunori Kadota.

Formation of drug–drug salt crystals and co-amorphous forms of levofloxacin and 4-aminosalicylic acid for pulmonary applications.

RSC Pharm., 2025, 2, 264.

Mayuka Nakajima, Neha Kapate, John R. Clegg, Mayumi Ikeda-Imafuku, Kyung Soo Park, Ninad Kumbhojkar, Vinny Chandran Suja, Supriya Prakash, Lily Li-Wen Wang, Koichi Tabeta, Samir Mitragotri.

Backpack-carrying macrophage immunotherapy for periodontitis.

Journal of Controlled Release.Volume 377, 10 January 2025, Pages 315-323

2024

Satohiro Nakao, Kazuki Shirakado, Kana Tamura, Reiri Koga, Mayumi Ikeda-Imafuku, Yu Ishima, Naomi Nakagata, Toru Takeo.

Oxidation of thiol groups in membrane proteins inhibits the fertilization ability and motility of sperm by suppressing calcium influx.

Biology of Reproduction, 2024;, ioae183

Kazuya Sugimoto,Hiromasa Uchiyama,Kazunori Kadota,Ken Yuki,and Yuichi Tozuka.

Elucidating the Factors Affecting the Patient-Centric Usability of Blister Packs for Spherical Capsules.

Chemical & Pharmaceutical Bulletin. 72, 1048–1054 (2024)

Kenta Ando,Hiromasa Uchiyama,Katsuhiko Minoura,Kazunori Kadota,and Yuichi Tozuka.

The Impact of Adding a Cationic Metal Salt and Curcumin to Monoammonium Glycyrrhizic Acid on Its Solubilizing Capacity and Gelation.

Chemical and Pharmaceutical Bulletin.2024 Volume 72 Issue 9 Pages 838-844

Yuhei Tsugawa, Kazunori Kadota, Mikio Yoshida, Yoshiyuki Shirakawa.Utilizing the phase-field method to investigate liquid-liquid phase separation in the ternary system of water/ethanol/butylparaben. Chemical Engineering Research and Design.Volume 210, October 2024, Pages 339-351

Tatsuya Fukuta, Ninad Kumbhojkar, Supriya Prakash, Suyog Shaha, A. Da Silva-Candal, Kyung Soo Park, Samir Mitragotri.

Immunotherapy against glioblastoma using backpack-activated neutrophils.

Bioengineering & Translational Medicine.13 August 2024 https://doi.org/10.1002/btm2.10712

Yan C, Nakajima M, Ikeda-Imafuku Mayumi, Yanagawa M, Hayatsu M, Fukuta Tatsuya, Shibata S, Mitragotri S, Tabeta K.

Choline and geranate ionic liquid for subgingival biofilm control.

Int J Pharm. 2024 Jul 31;662:124544. doi: 10.1016/j.ijpharm.2024.124544. Epub ahead of print. PMID: 39094920.

Peiwen Mo, Yuta Hatanaka,Shingo Furukawa, Mai Takase, Shinya Yamanaka,Mitsunobu Doi,Tero Kämäräinen,Hiromasa Uchiyama, Kazunori Kadota , Yuichi Tozuka.

Cocrystal formulation design of 4-Aminosalicylic acid and isoniazid via spray-drying based on a ternary phase diagram toward simultaneous pulmonary delivery.

Powder Technology.Volume 445, 1 September 2024, 120126

Kumi Semba,Kazunori Kadota,Tero Kämäräinen,Yuzuki Nakayam,Yuta Hatanaka,Hiromasa Uchiyama,Hiroshi Arima-Osonoi,Kazumasa Sugiyama,Yuichi Tozuka.

Tailored Sugar-Mediated Porous Particle Structures for Improved Dispersion of Drug Nanoparticles in Spray-Freeze-Drying.

Langmuir 2024, 40, 28, 14440–14454

Kazunori Kadota, Uchiyama, H., Kämäräinen, T., Tanaka, S., & Tozuka, Y.

Building respirable powder architectures: utilizing polysaccharides for precise control of particle morphology for enhanced pulmonary drug delivery.

Expert Opinion on Drug Delivery, 21(6), 945–963. https://doi.org/10.1080/17425247.2024.2376702

Tero Kämäräinen, Satoshi Nogami, Hiroshi Arima-Osonoi, Hiroki Iwase, Hiromasa Uchiyama, Yuichi Tozuka, Kazunori Kadota. Multiscale structure analysis of a pH-responsive gelatin/hydroxypropyl methylcellulose phthalate blend using small-angle scattering. Journal of Colloid and Interface Science. Volume 669, September 2024, Pages 975-983

Fukuda E, Fujiwara I, Maruno S, Motomura K, Endo S, Iwasaki A, Fukuta Tatsuya, Nakayama A, Shinada T.

Total Synthesis of Bipenicilisorin and Assignment of the Absolute Configuration.

J Nat Prod. 2024 May 5. doi: 10.1021/acs.jnatprod.4c00114. Epub ahead of print. PMID: 38706257.

Ninad Kumbhojkar, Supriya Prakash, Tatsuya Fukuta, Kwasi Adu-Berchie, Neha Kapate, Rocky An, Solomina Darko, Vineeth Chandran Suja, Kyung Soo Park, Alexander P. Gottlieb, Michael Griffith Bibbey, Malini Mukherji, Lily Li-Wen Wang, David J. Mooney & Samir Mitragotri.

Neutrophils bearing adhesive polymer micropatches as a drug-free cancer immunotherapy.

Nature Biomedical Engineering (2024). https://doi.org/10.1038/s41551-024-01180-z

Rie Mukai, Hitomi Okuyama, Miku Uchimura, Kozue Sakao, Miyu Matsuhiro, Mayumi Ikeda-Imafuku, Yu Ishima, Miyu Nishikawa, Shinichi Ikushiro, Akihiro Tai.

The binding selectivity of quercetin and its structure-related polyphenols to human serum albumin using a fluorescent dye cocktail for multiplex drug-site mapping.

Bioorganic Chemistry. https://doi.org/10.1016/j.bioorg.2024.107184

Mayumi Ikeda-Imafuku, Tatsuya Fukuta, Victor Tuan Giam Chuang, Tomohiro Sawa, Toru Maruyama, Masaki Otagiri, Tatsuhiro Ishida and Yu Ishima.

Acute Kidney Injury Caused by Rhabdomyolysis Is Ameliorated by Serum Albumin-Based Supersulfide Donors through Antioxidative Pathways.

Pharmaceuticals.( 2024), 17, 128. https://doi.org/10.3390/ph17010128

池田真由美，福田達也，岩尾康範，小田切優樹，丸山徹，石田竜弘，異島優.

血清アルブミンに存在する超硫黄の解析と創薬応用

Characterization of Supersulfide in Serum Albumin and Its Therapeutic Application.YAKUGAKU ZASSHI 144, 51–56 (2024)

2023

Tatsuya Fukuta, Mayumi Ikeda-Imafuku, Kodama, S., Kuse, J., Matsui, K., Iwao Yasunori.* (2023).

One-Step Pharmaceutical Preparation of PEG-Modified Exosomes Encapsulating Anti-Cancer Drugs by a High-Pressure Homogenization Technique.

Pharmaceuticals, 16(1), 108.(*Corresponding author)

Gao, Y, Mayumi Ikeda-Imafuku, Zhao, Z., Joshi, M., Mitragotri, S. (2023).

A polymer-based systemic hemostat for managing uncontrolled bleeding.

Bioengineering & Translational Medicine, e10516.

Rabab A Husseini, Tatsuya Fukuta, Mizune Ozono, Azza A Hasan, Nagia A El Megrab, Kentaro Kogure.

The Effect of Iontophoretic-Delivered Polyplex Vaccine on Melanoma Regression.

Biol Pharm Bull. 2023;46(3):494-504. doi: 10.1248/bpb.b22-00873.

Tatsuya Fukuta, Mayumi Ikeda-Imafuku, Iwao,Y.(2023).

Development of Edaravone Ionic Liquids and Their Application for the Treatment of Cerebral Ischemia/Reperfusion Injury . Molecular Pharmaceutics,mp-2023-001038.

Sakakibara, O.; Shimoda, M.; Yamamoto, G.; Higashi, Y.; Mayumi Ikeda-Imafuku; Ishima, Y.; Kawahara, M.; Tanaka, K. Effectiveness of Albumin-Fused Thioredoxin against 6-Hydroxydopamine-Induced Neurotoxicity In Vitro. Int. J.

Molecular Sciences 2023, 24, 9758.

Tatsuya Fukuta,*,a Akina Nishikawa,b Ami Hiramachi,c Sachika Yamashita,c and Kentaro Kogure.(2023).

Development of Functional Chimeric Nanoparticles by Membrane Fusion of Small Extracellular Vesicles and Drug-Encapsulated Liposomes.

Biological and Pharmaceutical Bulletin, 46, 1098–1104 (2023)

Kengo Yasuda, Hitoshi Maeda, Ryo Kinoshita, Yuki Minayoshi, Yuki Mizuta, Yuka Nakamura, Shuhei Imoto, Koji Nishi, Keishi Yamasaki, Mina Sakuragi, Teruya Nakamura, Mayumi Ikeda-Imafuku, Yasunori Iwao, Yu Ishima, Tatsuhiro Ishida, Yasuko Iwakiri, Masaki Otagiri, Hiroshi Watanabe and Toru Maruyama(2023).

Encapsulation of an Antioxidant in Redox-Sensitive Self-Assembled Albumin Nanoparticles for the Treatment of Hepatitis.

ACS Nano,3c02877

Hiroyuki Koide, Chiaki Kiyokawa, Anna Okishima, Kaito Saito, Keiichi Yoshimatsu, Tatsuya Fukuta, Yu Hoshino, Tomohiro Asai, Yuri Nishimura, Yoshiko Miura, Naoto Oku and Kenneth J. Shea.(2023).

Design of an Anti-HMGB1 Synthetic Antibody for In Vivo Ischemic/Reperfusion Injury Therapy.

Journal of the American Chemical Society Volume 145, Issue 42 October 25, (2023) Pages22857-23394

Takeru Hirai , Mayumi Ikeda-Imafuku , Nanami Tasaka , Victor Tuan Giam Chung, Ming Xian ,Tatsuhiro Ishida , Takaaki Akaike , Yu Ishima.(2023).

Human hair keratin responds to oxidative stress via reactive sulfur and supersulfides.

Advances in Redox Research.Volume 10, April 2024, 100091

2022

Khatun, A., Hasan, M., Abd El-Emam, M. M., Tatsuya Fukuta, Mimura, M., Tashima, R., ... & Kogure, K. (2022).

Effective Anticancer Therapy by Combination of Nanoparticles Encapsulating Chemotherapeutic Agents and Weak Electric Current. Biological and Pharmaceutical Bulletin, 45(2), 194-199.

Tatsuya Fukuta*, Oku, N., & Kogure, K. (2022).

Application and Utility of Liposomal Neuroprotective Agents and Biomimetic Nanoparticles for the Treatment of Ischemic Stroke. Pharmaceutics, 14(2), 361. (*Corresponding author)

Hasan, M.#, Tatsuya Fukuta, Inoue, S., Mori, H., Kagawa, M., & Kogure, K. (2022).

Iontophoresis-mediated direct delivery of nucleic acid therapeutics, without use of carriers, to internal organs via non-blood circulatory pathways.

Journal of Controlled Release, 343, 392-399. (#Equal contribution)

Mayumi Ikeda-Imafuku, Wang, L. L. W., Rodrigues, D., Shaha, S., Zhao, Z., & Mitragotri, S. (2022).

Strategies to improve the EPR effect: A mechanistic perspective and clinical translation.

Journal of Controlled Release, 345, 512-536.

Tatsuya Fukuta, and Kogure, K. (2022).

Biomimetic Nanoparticle Drug Delivery Systems to Overcome Biological Barriers for Therapeutic Applications.

Chemical and Pharmaceutical Bulletin 70.5, 334-340.

Yoneda, S.#, Tatsuya Fukuta, Ozono, M., Kogure, K. (2022).

Enhancement of cerebroprotective effects of lipid nanoparticles encapsulating FK506 on cerebral ischemia/reperfusion injury by particle size regulation.

Biochemical and Biophysical Research Communications, 611, 53-59.

Mayumi Ikeda-Imafuku, Gao, Y., Shaha, S., Wang, L. L., Park, K. S., Nakajima, M., Adebowa, O. & Mitragotri, S. (2022). Extracellular matrix degrading enzyme with stroma-targeting peptides enhance the penetration of liposomes into tumors.

Journal of Controlled Release, 352, 1093-1103.